Jie (Jack) Hu, postdoctoral fellow

Dr. Hu is research fellow in the Division of Women’s Health at Brigham and Women’s Hospital and Harvard Medical School. He is also a postdoctoral research fellow in the Department of Epidemiology at Harvard T.H. Chan School of Public Health.

 

He obtained his MD from Tongji Medical College and his PhD from the School of Public Health at Huazhong University of Science and Technology, China. Dr. Hu was a Visiting Scholar in Department of Epidemiology at Brown University School of Public Health, Providence, RI.

 

During his PhD and time as Visiting Scholar, Dr. Hu conducted multiple epidemiological and epigenome-wide studies investigating environmental exposures and behavioral risk factors related to maternal health, fetal growth, and human aging in several cohorts in China.

 

PubMed bibliography

Harvard Catalyst profile

 

 

Research fellow in medicine, Brigham and Women’s Hospital and Harvard Medical School

Postdoctoral research fellow, Harvard T.H. Chan School of Public Health

Areas of Expertise

Current Research

Dr. Hu’s current research primarily focuses on the investigation of risk factors and underlying mechanisms of coronary heart disease, ischemic stroke, and type 2 diabetes. He is leading several multi-cohort projects identifying hormonal, inflammatory, metabolomic, and genetic factors related to cardiometabolic risk, using data from the Women’s Health Initiative, Nurses’ Health Studies, Health Professional Follow-up Study, Multi-Ethnic Study of Atherosclerosis, and UK Biobank. Dr. Hu is also leading and actively involved in several consortium metabolomics and epigenetics projects in the Trans-Omics for Precision Medicine (TOPMed), Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE), and COnsortium of METabolomics Studies (COMETS).

 
Funding

 

  • Metabolomic Response to Hormone Therapy and Ischemic Stroke in Postmenopausal Women (Women’s Brain Initiative Research Fellowship Program, BWH Program for Interdisciplinary Neuroscience, PI)

Select Publications

Li J, Lee D-H, Hu J, Tabung FK, Li Y, Bhupathiraju SN, Rimm EB, Rexrode KM, Manson JE, Willett WC, Giovannucci EL, Hu FB. Dietary Inflammatory Potential and Risk of Cardiovascular Disease. J Am Coll Cardiol. 2020 Nov;76(19):2181-2193. PMID: 33153576.

 

Li J, Guasch-Ferré M, Chung W, Ruiz-Canela M, Toledo E, Corella D, Bhupathiraju SN, Tobias DK, Tabung FK, Hu J, Zhao T, Turman C, Feng YA, Clish CB, Mucci L, Eliassen AH, Costenbader KH, Karlson EW, Wolpin BM, Ascherio A, Rimm EB, Manson JE, Qi L, Martínez-González MÁ, Salas-Salvadó J, Hu FB, Liang L. Mediterranean diet adherence, plasma metabolome, and cardiovascular disease. Eur Heart J. 2020 Jul;41(28):2645-2656. PMID: 32406924.

 

Hu J, Lin JH, Jiménez MC, Manson JE, Hankinson SE, Rexrode KM. Plasma Estradiol and Testosterone levels and Ischemic Stroke in Postmenopausal Women. Stroke. 2020 Feb 14:STROKEAHA119028588. PMID: 32078496.

 

Hu J, Zhao H, Braun JM, Zheng T, Zhang B, Xia W, Zhang W, Li JF, Zhou Y, Li H, Li J, Zhou A, Zhang Y, Buka SL, Liu S, Peng Y, Wu C, Jiang M, Huo W, Zhu Y, Shi K, Li Y, Cai Z, Xu S. Associations of Trimester-specific Exposure to Bisphenols with Size at Birth: A Chinese Prenatal Cohort Study. Environ Health Perspect. 2019 Oct;127(10):107001. PMID: 31573832.

 

Ding M, Zeleznik OA, Guasch-Ferré M, Hu J, Lasky-Su J, Lee IM, Jackson RD, Shadyab AH, LaMonte MJ, Clish C, Eliassen AH, Sacks F, Willett WC, Hu FB, Rexrode KM, Kraft P. Metabolome-wide Association Study with Habitual Physical Activity in Four Prospective Cohort Studies. Am J Epidemiol. 2019 Jul 31. PMID: 31364705.

 

Hu J, Li Y, Zhang B, Zheng T, Li J, Peng Y, Zhou A, Buka SL, Liu S, Zhang Y, Shi K, Xia W, Rexrode KM, Xu S. Impact of the 2017 ACC/AHA Guideline for High Blood Pressure on Evaluating Gestational Hypertension Associated Risks for Newborns and Mothers: A Retrospective Birth Cohort Study. Circ Res. 2019 May 20. PMID: 31104583.

 

Hu J, Wu C, Zheng T, Zhang B, Xia W, Peng Y, Liu W, Jiang M, Liu S, Buka SL, Zhou A, Zhang Y, Jiang Y, Hu C, Chen X, Zeng Q, Chen X, Xu B, Zhang X, Truong A, Shi K, Qian Z, Li Y, Xu S. Critical Windows for Associations between Manganese Exposure during Pregnancy and Size at Birth: A Longitudinal Cohort Study in Wuhan, China. Environ Health Perspect. 2018 Dec;126(12):127006. PMID: 30675808.

 

Hu J, Peng Y, Zheng T, Zhang B, Liu W, Wu C, Jiang M, Braun JM, Liu S, Buka SL, Zhou A, Wise JP Sr, Zhang Y, Jiang Y, Hu C, Chen X, Huang Z, Zheng D, Shi K, Zhang X, Truong A, Qian Z, Xia W, Li Y, Xu S. Effects of trimester-specific exposure to vanadium on ultrasound measures of fetal growth and birth size: a longitudinal prospective prenatal cohort study. Lancet Planet Health. 2018 Oct;2(10):e427-e437. PMID: 30318100.

 

Li J, Zhu X, Yu K, Jiang H, Zhang Y, Wang B, Liu X, Deng S, Hu J, Deng Q, Sun H, Guo H, Zhang X, Chen W, Yuan J, He M, Bai Y, Han X, Liu B, Liu C, Guo Y, Zhang B, Zhang Z, Hu FB, Gao W, Li L, Lathrop M, Laprise C, Liang L, Wu T. Exposure to Polycyclic Aromatic Hydrocarbons and Accelerated DNA Methylation Aging. Environ Health Perspect. 2018 Jun 14;126(6):067005. PMID: 29906262.

 

Hu J, Xia W, Pan X, Zheng T, Zhang B, Zhou A, Buka SL, Bassig BA, Liu W, Wu C, Peng Y, Li J, Zhang C, Liu H, Jiang M, Wang Y, Zhang J, Huang Z, Zheng D, Shi K, Qian Z, Li Y, Xu S. Association of adverse birth outcomes with prenatal exposure to vanadium: a population-based cohort study. Lancet Planet Health. 2017 Sep; 1(6):e230-e241. Epub 2017 Sep 7. PMID: 29851608.

 

Zhu X, Li J, Deng S, Yu K, Liu X, Deng Q, Sun H, Zhang X, He M, Guo H, Chen W, Yuan J, Zhang B, Kuang D, He X, Bai Y, Han X, Liu B, Li X, Yang L, Jiang H, Zhang Y, Hu J, Cheng L, Luo X, Mei W, Zhou Z, Sun S, Zhang L, Liu C, Guo Y, Zhang Z, Hu FB, Liang L, Wu T. Genome-wide analysis of DNA methylation and cigarette smoking in a Chinese population. Environ Health Perspect. 2016 Jul;124(7):966-73. PMID: 26756918.