Dr. Kevin Sanchez is a postdoctoral research fellow in the Division of Women’s Health. He also has a dual appointment as a research fellow at Harvard Medical School. Dr. Sanchez received his PhD in Pharmacology & Toxicology from the University of Texas at Austin.
During his PhD, Dr. Sanchez investigated sex differences in the neuroimmune system throughout the lifespan using in vivo models. For example, he led a project where single nuclei RNA sequencing was conducted on rat hippocampal tissue to assess age- and sex-dependent changes in their immune profiles. His transcriptomic data indicate that the brains of healthy, aged female rats present a less neurodegenerative profile than their aged male counterparts. This may be due to females having a greater bias towards an adaptive immune response.
Dr. Sanchez is also invested in research that evaluates the impacts of environmental exposures on health outcomes. As a graduate student, he participated in a collaborative project to determine whether perinatal exposure to polychlorinated biphenyls, a persistent environmental endocrine-disrupting chemical, would impact neuroimmune function and behavior during adolescence. Their results indicate that perinatal polychlorinated biphenyl exposure enhanced neuroinflammation and anxiety-like behaviors in adolescent male rats but not female rats.
Research Fellow, Brigham and Women’s Hospital; Research Fellow, Harvard Medical School
Dr. Sanchez is currently working with Dr. Kathryn Rexrode to untangle the influence of metabolomic and proteomic data types in the risk of cardiovascular disease, with a focus on sex differences and the incidence of these conditions in women. He will be leveraging data from various study cohorts, such as the Nurses Health Study (NHS) cohorts and the UK Biobank, to address the gap in understanding of the biological processes that mediate the increased risk of cardiovascular diseases in women.
Sanchez K, Wu S, Kakkar R, Darling JS, Daniels R, Harper CS, Fonken LK. Ovariectomy in adult mice primes hippocampal microglia to exacerbate behavioral sickness responses. Brain Behav Immun Health. 2023 May 18;30:100638. PMID: 37256192
Ince LM, Darling JS, Sanchez K, Bell KS, Melbourne JK, Davis LK, Nixon K, Gaudet AD, Fonken LK. Sex differences in microglia function in aged rats underlie vulnerability to cognitive decline. Brain Behav Immun. 2023 Nov 1;114:438-452. PMID: 37709153
Hussain T, Sanchez K, Crayton J, Saha D, Jeter C, Lu Y, Abba M, Seo R, Noebels JL, Fonken LK, Aldaz CM. WWOX P47T loss-of-function mutation induces epilepsy, progressive neuroinflammation, and cerebellar degeneration. Prog Neurobiol. 2023 Apr;223:102425. PMID: 36828035
Sanchez K, Darling JS, Kakkar R, Wu S, Zentay A, Lowry CA, Fonken LK. Mycobacterium vaccae immunization in rats ameliorates age-associated microglia activation in the hippocampus. Sci Rep. 2022 Feb 9;12(1):2165. PMID: 35140249
Sanchez K, Guerin SP, Fonken LK. Anxiety in obesity: is neuroinflammation the critical link? Brain Behav Immun. 2019 May 1;78:7-8. PMID: 30654006
Robbins CJ, Bou-Dargham MJ, Sanchez K, Rosen MC, Sang QX. Decoding somatic driver gene mutations and affected signaling pathways in human medulloblastoma subgroups. J Cancer. 2018 Nov 17;9(24):4596-4610. PMID: 30588243
Research Program of the Division of Women’s Health
Department of Medicine, Brigham and Women’s Hospital
75 Francis Street, Boston MA 02115